Sarah Jenkinson
Stipendiary Lecturer in Organic Chemistry
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Contact information
Teaching
I teach all 3 years of the Organic Chemistry course at Univ, as well as the 1st year Organic Chemistry course for the Biochemists. I also co-organise and lecture the 1st聽year Organic Chemistry course for the Department of Biochemistry.
Research
My research is focused in the area of carbohydrate chemistry with an emphasis on the synthesis of rare and branched sugars as building blocks for drug development. Specific targets include diabetes and cystic fibrosis drugs as well as anti-cancer agents.
Selected Publications
Glawar, A. F. G.; Mart铆nez, R. F.; Ayers, B. J.; Hollas, M. A.; Ngo, N.; Nakagawa, S.; Kato, A.; Butters, T.D.; Fleet, G. W. J.; Jenkinson, S. F., Structural essentials for 尾-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids, Org. Biomol. Chem. 2016, 14, 10371-10385.
Liu, Z.; Yoshihara, A.; Jenkinson, S. F.; Wormald, M. R.; Estevez, R. J.; Fleet, G. W. J.; Izumori, K., Triacetonide of Glucoheptonic Acid in the Scalable Syntheses of D-Gulose, 6-Deoxy-D-gulose, L-Glucose, 6-Deoxy-L-glucose and Related Sugars,聽Org. Lett. 2016,听18, 4112鈥�4115.
Liu, Z.; Jenkinson, S. F.; Kato, A.; Nakagawa, S.; Wormald, M. R.; Yu, C.-Y.; Fleet, G. W. J., Azidoazetidines as the first scaffolds for 尾-amino azetidine carboxylic acid peptidomimetics: azetidine iminosugars containing an acetamido group do not聽inhibit 尾-N-acetylhexosaminidases, Tetrahedron: Asymmetry 2016, 27, 872-881.
Liu, Z.; Jenkinson, S. F.; Vermaas, T.; Adachi, I.; Wormald, M. R.; Hata, Y.; Kurashima, Y.; Kaji, A.; Yu, C.-Y.; Kato, A.; Fleet, G. W. J., 3-Fluoro-azetidine Carboxylic Acids and聽trans,trans-3,4-Difluoroproline as Peptide Scaffolds: Inhibition of Pancreatic Cancer Cell Growth by a Fluoroazetidine Iminosugar,聽J. Org. Chem.听2015,听80,听4244鈥�4258.
Ayers, B. J.; Glawar, A. F. G.;聽Mart铆nez, R. F.; Ngo, N.; Liu, Z.; Fleet, G. W. J.; Butters, T. D.; Nash, R. J.; Yu, C.-Y.; Wormald, M. R.; Nakagawa, S.; Adachi, I.; Kato, A.; Jenkinson, S. F., 9 of 16 Stereoisomeric Polyhydroxylated Proline Amides are Potent 尾-N-Acetylhexosaminidase Inhibitors,聽J. Org. Chem.听2014,听79, 3398-3409.
Mart铆nez, R. F.; Liu, Z.; Glawar, A. F. G; Yoshihara, A.; Izumori, K.; Fleet, G. W. J.; Jenkinson, S. F., Short and Sweet:聽D-Glucose to聽L-Glucose and聽L-Glucuronic Acid, Angew. Chem. Int. Edit.听2014,听53, 1160-1162; Kurz und Knapp:聽L-Glucose und聽L-Gluconsaure von聽D-Glucose, Angew. Chem.听2014,听126, 1179-1182.
Glawar, A. F. G.; Jenkinson, S. F.; Newberry, S. J.; Thompson, A. L.; Nakagawa, S.; Yoshihara, A.; Akimitsu, K.; Izumori, K.; Butters, T. D.; Kato, A.; Fleet, G. W. J., An approach to 8 stereoisomers of homonojirimycin from D-glucose via kinetic & thermodynamic azido-g-lactones, Org. Biomol. Chem. 2013, 11, 6886-6889.
Jenkinson, S. F., Best, D., Saville, A. W., Mui, J., Mart铆nez, R. F., Nakagawa, S., Kunimatsu, T., Alonzi, D. S., Butters, T. D., Norez, C., Becq, F., Bl茅riot, Y., Wilson, F. X., Weymouth-Wilson, A. C., Kato, A., Fleet, G. W. J., C-Branched Iminosugars: 伪-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP and isoDAB 鈥� L-isoDMDP Compared to Miglitol and Miglustat, J. Org. Chem. 2013, 78, 7380-7397.
Jenkinson, S. F.; Fleet, G. W. J.; Nash, R. J.; Koike, Y.; Adachi, I.; Yoshihara, A.; Morimoto, K.; Izumori, K.; Kato, A., Looking-glass synergistic pharmacological chaperones: DGJ and L-DGJ from the enantiomers of tagatose, Org. Lett. 2011, 13, 4064鈥�4067.
Jenkinson, S. F.; Fleet, G. W. J. Oxetanes from the ring contraction of 伪-triflates of g-lactones: oxetane nucleosides and oxetane amino acids, Chimia 2011, 65, 71-75.